1,3-Dimethoxybenzene → 1-(2,4-Dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

HRID 1434429Notes

Reaction equation

HRID 1434429 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[CH:4]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20](Cl)=[O:21])=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][CH3:10])[CH:6]=[CH:7][C:8]=1[C:20](=[O:21])[CH2:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 90251,3-DimethoxybenzeneHCID 27346884-Methoxyphenylacetyl chloride

Product 1

HCID 134271631-(2,4-Dimethoxyphenyl)-2-(4-methoxyphenyl)ethanoneYield 51.6%

Procedure

Synthesized from 1,3-dimethoxybenzene (8.2 g) and 4-methoxyphenylacetyl chloride (10.0 g) according to an analogous synthetic method to Preparation Example 66,the title compound (8.0 g) was obtained.

Sources & evidence

ORD record
ord-33994dc8dca14d5fbd5225a7e225e31d
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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