Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 11350205, compound

HRID 1434432Notes

Reaction equation

HRID 1434432 reaction equation
COC1C=CC(CC2C=CC=C(OC)C=2)=C(C2C=CC(O)=CC=2)C=1.Cl.ClCCN1CCCCC1.C[O:36][C:37]1[CH:38]=[CH:39][C:40]([CH2:58][C:59]2[CH:64]=[CH:63][CH:62]=[C:61]([O:65]C)[CH:60]=2)=[C:41]([C:43]2[CH:48]=[CH:47][C:46]([O:49][CH2:50][CH2:51][N:52]3[CH2:57][CH2:56][CH2:55][CH2:54][CH2:53]3)=[CH:45][CH:44]=2)[CH:42]=1>>[OH:65][C:61]1[CH:60]=[C:59]([CH:64]=[CH:63][CH:62]=1)[CH2:58][C:40]1[C:41]([C:43]2[CH:44]=[CH:45][C:46]([O:49][CH2:50][CH2:51][N:52]3[CH2:57][CH2:56][CH2:55][CH2:54][CH2:53]3)=[CH:47][CH:48]=2)=[CH:42][C:37]([OH:36])=[CH:38][CH:39]=1

Participants

4

Reactant 3

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 11370629HCID 11370629, compoundHCID 66627698HCID 66627698, compound

Product 1

HCID 11350205HCID 11350205, compoundYield 47.4%

Procedure

Synthesized from 5′-methoxy-2′-(3-methoxybenzyl)biphenyl-4-ol and 1-(2-chloroethyl)piperidine hydrochloride according to an analogous synthetic method to Preparation Example 40, 1-{2-[5′-methoxy-2′-(3-methoxybenzyl)biphenyl-4-yloxy]ethyl}piperidine (158 mg) was used according to an analogous synthetic method to Example 779 to provide the title compound (70 mg).

Sources & evidence

ORD record
ord-ff04407641c944a8a10b81e92c4f6d00
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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