4-Benzyloxy-phenylboronic acid → HCID 11450457, compound

HRID 1434433Notes

Reaction equation

HRID 1434433 reaction equation
FC(F)(F)S(OC1C=C(OC)C=CC=1CCC1C=CC(OC)=CC=1)(=O)=O.C(OC1C=CC(B(O)O)=CC=1)C1C=CC=CC=1.C([O:51][C:52]1[CH:57]=[CH:56][C:55]([C:58]2[CH:63]=[C:62]([O:64][CH3:65])[CH:61]=[CH:60][C:59]=2[CH2:66][CH2:67][C:68]2[CH:73]=[CH:72][C:71]([O:74][CH3:75])=[CH:70][CH:69]=2)=[CH:54][CH:53]=1)C1C=CC=CC=1>>[CH3:65][O:64][C:62]1[CH:61]=[CH:60][C:59]([CH2:66][CH2:67][C:68]2[CH:69]=[CH:70][C:71]([O:74][CH3:75])=[CH:72][CH:73]=2)=[C:58]([C:55]2[CH:54]=[CH:53][C:52]([OH:51])=[CH:57][CH:56]=2)[CH:63]=1

Participants

4

Reactant 3

HCID 27343144-Benzyloxy-phenylboronic acidHCID 11429224HCID 11429224, compoundHCID 23087067HCID 23087067, compound

Product 1

HCID 11450457HCID 11450457, compoundYield 88.2%

Procedure

Synthesized from 5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl trifluoromethanesulfonate and 4-benzyloxyphenylboronic acid according to an analogous synthetic method to Example 24, 4′-benzyloxy-5-methoxy-2-[2-(4-methoxyphenyl)ethyl]biphenyl (600 mg) was used according to an analogous synthetic method to Example 22 to provide the title compound (417 mg).

Sources & evidence

ORD record
ord-059c941dbb5a43af96214da01f810b30
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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