Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 11774402, compound

HRID 1434436Notes

Reaction equation

HRID 1434436 reaction equation
COC1C=CC(CCC2C=CC(OC)=CC=2)=C(C2C=CC=C(O)C=2)C=1.Cl.ClCCN1CCCCC1.C[O:37][C:38]1[CH:39]=[CH:40][C:41]([CH2:59][CH2:60][C:61]2[CH:66]=[CH:65][C:64]([O:67]C)=[CH:63][CH:62]=2)=[C:42]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([O:50][CH2:51][CH2:52][N:53]3[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54]3)[CH:45]=2)[CH:43]=1>>[OH:67][C:64]1[CH:63]=[CH:62][C:61]([CH2:60][CH2:59][C:41]2[C:42]([C:44]3[CH:49]=[CH:48][CH:47]=[C:46]([O:50][CH2:51][CH2:52][N:53]4[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54]4)[CH:45]=3)=[CH:43][C:38]([OH:37])=[CH:39][CH:40]=2)=[CH:66][CH:65]=1

Participants

4

Reactant 3

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 11336578HCID 11336578, compoundHCID 23087202HCID 23087202, compound

Product 1

HCID 11774402HCID 11774402, compoundYield 65.1%

Procedure

Synthesized from 5′-methoxy-2′-[2-(4-methoxyphenyl)ethyl]biphenyl-3-ol and 1-(2-chloroethyl)piperidine hydrochloride according to an analogous synthetic method to Preparation Example 40, 1-{2-{5′-methoxy-2′-[2-(4-methoxyphenyl)ethyl]biphenyl-3-yloxy}ethyl}piperidine (200 mg) was used according to an analogous synthetic method to Example 779 to provide the title compound (122 mg).

Sources & evidence

ORD record
ord-76d2487107324b9089f03ef290f8e046
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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