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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434456Generated: November 2, 2026

Propanoic acid, 2,2-dimethyl-, (6R)-6-[2-(ethylamino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenyl ester → HCID 57934023, compound

https://huagongshe.com/reaction/1434456

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPropanoic acid, 2,2-dimethyl-, (6R)-6-[2-(ethylamino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenyl esterHCID 57934253—
ReactantHCID 66625977HCID 66625977—
ReactantHCID 66627376HCID 66627376—
ProductHCID 57934023HCID 5793402343.1%

Reaction Steps

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (100 mg) and 4-[2-(tert-butoxycarbonylethylamino)-2-methylpropyl]benzoic acid (125 mg) according to analogous synthetic method to Preparation Example 86, pivalic acid 6-{2-{{4-[2-(tert-butoxycarbonylethylamino)-2-methylpropyl]benzoyl}ethylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (94 mg) was used according to an analogous synthetic method to the above-mentioned Example 215 and Example 337 to provide the title compound (55 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07612114B2
Source datasetuspto-grants-2009_11
ORD IDord-2be0f54c7342433387ccfb2f51626d6c
Source noteuspto-grants-2009_11