4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester → HCID 57934525, compound

HRID 1434459Notes

Reaction equation

HRID 1434459 reaction equation
C([O:3][C:4]([CH2:6][NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[CH:10][C:9]=1[C@H:18]1[CH2:27][CH2:26][C:25]2[CH:24]=[C:23]([O:28]C(=O)C(C)(C)C)[CH:22]=[CH:21][C:20]=2[CH2:19]1)=O)C.C(O[C:40]([N:42]1[CH2:47][CH2:46][CH:45]([C:48]2[CH:53]=[CH:52][C:51]([C:54](O)=O)=[CH:50][CH:49]=2)[CH2:44][CH2:43]1)=O)(C)(C)C>>[OH:3][CH2:4][CH2:6][N:7]([CH2:54][C:51]1[CH:50]=[CH:49][C:48]([CH:45]2[CH2:44][CH2:43][N:42]([CH3:40])[CH2:47][CH2:46]2)=[CH:53][CH:52]=1)[C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[CH:10][C:9]=1[C@H:18]1[CH2:27][CH2:26][C:25]2[CH:24]=[C:23]([OH:28])[CH:22]=[CH:21][C:20]=2[CH2:19]1

Participants

3

Reactant 2

HCID 224928594-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl esterHCID 57933915HCID 57933915, compound

Product 1

HCID 57934525HCID 57934525, compoundYield 36.4%

Procedure

Synthesized from pivalic acid (S)-6-[2-(ethoxycarbonylmethylamino)-4,5-dimethoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-yl ester (90 mg) and 4-(4-carboxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (88 mg) according to an analogous synthetic method to the above-mentioned Preparation Example 86 and Example 337, the title compound (37 mg) was obtained.

Workup

  1. customaccording to an analogous synthetic method to the above-mentioned Preparation Example 86 and Example 337

Sources & evidence

ORD record
ord-984dbd318c39468cbdbeaa63b2f82e22
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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