HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 843666-31-9
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate | HCID 9857522 | — |
| Reactant | HCID 27282474 | HCID 27282474 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 843666-31-9 | HCID 58419211 | 100% |
Reaction Steps
Mono-benzyl octadecandioate was dissolved in DMF (3.5 mL) and THF (7 mL) and cooled with ice bath. DIEA (0.103 mL) and TSTU were added and the mixture was stirred 1 h at ice bath and at RT overnight. The solvent was evaporated in vacuo and the residue was dissolved in AcOEt and washed twice with 0.2 N HCl, saturated NaHCO3, dried, filtered and evaporated to dryness to give succinimidyl mono-benzyl octadecandioate (0.25 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615532B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4e1c884e98464aa898ba4db1e76dbc33 |
| Source note | uspto-grants-2009_11 |