Tributylphosphine → HCID 86605953, compound

Participants

Reaction Steps

310 mg (0.7 mmol) benzyl (2-hydroxy-(1R)-1-{[2-fluoro-4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-methyl}-ethyl)-carbamate are dissolved in 3.5 ml THF. While cooling with ice a mixture of 205 mg (0.89 mmol) di-tert.-butyl azodicarboxylate and 210 μl (0.83 mmol) tributylphosphine in 6 ml THF is added. The mixture is slowly heated to ambient temperature and stirred for 16 hours. The mixture is then evaporated to dryness. The residue is purified by reversed-phase chromatography.

Provenance & Evidence