Trifluoroacetic acid → HCID 86605958, compound

Participants

Reaction Steps

1.52 g (6.89 mmol) 3-(4-amino-2-methyl-phenyl)-[1,3]oxazepan-2-one and 1.0 g (6.89 mmol) methyl 3-nitro-but-3-enoate (prepared analogously to M. Mühlstädt, B. Schulze J. Prakt. Chem. 1971, 313(4), 745-753) are melted together at 130° C. for 50 minutes. The mixture is allowed to cool and dissolved in DMF. The solution is acidified with TFA and purified by chromatography using reversed phase HPLC.

Provenance & Evidence