p-Fluoronitrobenzene → 2-(4-Nitrophenyl)-[1,2]thiazinane-1,1-dioxide

Participants

Reaction Steps

500 mg (3.7 mmol) [1,2]thiazinane-1,1-dioxide, dissolved in 10 ml DMF, are added to a suspension of 163 mg sodium hydride dispersion in mineral oil (60%, 4.07 mmol) in 5 ml DMF. The mixture is stirred for 15 minutes, then a solution of 522 mg (3.7 mmol) 1-fluoro-4-nitrobenzene in 10 ml DMF is added dropwise. After two hours the reaction mixture is poured onto ice water. The solid is filtered off, washed with water and dried.

Provenance & Evidence