HuagongsheHuagongshe Chemistry Print Report · For research reference only
PyBOP → 5-Fluoro-1-methyl-3-{[4-(4-{[3-(1-piperidinyl)propyl]oxy}phenyl)-1-piperazinyl]carbonyl}-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | PyBOP | HCID 2724699 | — |
| Reactant | 1-[4-(3-Piperidin-1-ylpropoxy)phenyl]piperazine | HCID 9924013 | — |
| Reactant | 5-fluoro-1-methyl-1H-indole-3-carboxylic acid | HCID 18385102 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Fluoro-1-methyl-3-{[4-(4-{[3-(1-piperidinyl)propyl]oxy}phenyl)-1-piperazinyl]carbonyl}-1H-indole | HCID 57935847 | 15.2% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A solution of 5-fluoro-1-methyl-1H-indole-3-carboxylic acid [WO 0071537 A1] (35 mg) and 1-(4-{[3-(1-piperidinyl)propyl]oxy}phenyl)piperazine (D11) (50 mg) in dichloromethane (1 ml) was treated with benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate (94.4 mg) and heated in a microwave (CEM™ Discover microwave) at 120° C. for 5 min. The reaction mixture was concentrated in vacuo and purified on a SCX cartridge (2 g) eluting with methanol-aqueous ammonia (10:1) followed by mass directed auto preparative HPLC to give the title compound (12 mg). LCMS RT=2.49 min, 478 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615550B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-81824e8f11314bc1a7d9ea2905217a3d |
| Source note | uspto-grants-2009_11 |