反应详情

Sodium borohydride (189 mg) was added to a solution of 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-one (2.07 g) in ethanol (40 ml) at 0° C., the mixture was allowed to warm to room temperature and was stirred for 16 hours. The reaction mixture was evaporated to dryness, the residue was redissolved in dichloromethane and washed with water (15 ml) and brine (15 ml) and dried. Removal of the solvent gave 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-ol, 2.1 g, M+H 414.

1. customThe reaction mixture was evaporated to dryness
2. dissolutionthe residue was redissolved in dichloromethane
3. washwashed with water (15 ml) and brine (15 ml)
4. customdried
5. customRemoval of the solvent