1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid → 4-(3-Benzyl-[1,2,4]oxadiazol-5-yl)-piperidine hydrochloride

Participants

Reaction Steps

This was prepared from N′-hydroxy-2-phenylethanimidamide and 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid using a similar method to that used to prepare 4-{3-[4-(methylthio)benzyl]-1,2,4-oxadiazol-5-yl}piperidine hydrochloride (Method E, Steps 1, 2); NMR: 1.96 (2H, m), 2.15(2H, dd), 3.01(2H, t), 3.24 (2H, dd), 3.40 (1H, m), 4.09 (2H, s), 7.25 (5H, m), 9.31(2H, br s); MS: 244 (MH+).

Provenance & Evidence