Acetic Anhydride → HCID 57935989, compound

HRID 1434618Notes

Reaction equation

HRID 1434618 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]=[N:17][N:16]=[CH:15]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:15]=[N:16][N:17]=[C:18]2[C:19](=[O:21])[CH3:20])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 21098257HCID 21098257, compound

Product 1

HCID 57935989HCID 57935989, compound

Procedure

A solution of 1-benzyl-4-(4H-1,2,4-triazol-4-yl)piperidine (200 mg) in acetic anhydride (20 ml) was refluxed for 18 hours. The reaction mixture was concentrated under reduced pressure to a thick oil. Flash chromatography eluting with dischloromethane then 5% methanol in dichloromethane gave 1-[4-(1-benzylpiperidin-4-yl)-4H-1,2,4-triazol-3-yl]ethanone as a colourless oil (60 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure to a thick oil
  2. washFlash chromatography eluting with dischloromethane

Sources & evidence

ORD record
ord-dfcd9b83444f423b8a0a1e4b997feb9c
Source dataset
uspto-grants-2009_11
Patent number
US07615555B2

Reaction notes

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