Aluminium lithium hydride → HCID 20099412, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(4-chlorophenyl)-6,6-dimethylpiperazine-2,5-dione (0.9 g, 3.56 mmol) in THF (100 mL) at 0° C., was added LiAlH4 (0.54 g, 14.2 mmol) portionwise. The reaction was stirred at 0° C. for 0.5 h, the reaction was warmed to rt and stirred for 1 h. The reaction was carefully quenched with water, diluted with EtOAc, and added solid NaHCO3. The solution was stirred, filtered, and concentrated to give to give 1-(4-chlorophenyl)-2,2-dimethylpiperazine (0.76 g, 3.38 mmol, 95% yield) as a yellow oil.

Provenance & Evidence