Hydrazine → 2-(3,4-dichlorophenyl)acetohydrazide

HRID 1434675Notes

Reaction equation

HRID 1434675 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([Cl:12])[CH:6]=1.[NH2:14][NH2:15]>C(O)C>[Cl:12][C:7]1[CH:6]=[C:5]([CH2:4][C:3]([NH:14][NH2:15])=[O:2])[CH:10]=[CH:9][C:8]=1[Cl:11]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 1268257Methyl 2-(3,4-dichlorophenyl)acetate

Product 1

HCID 27360342-(3,4-dichlorophenyl)acetohydrazideYield 96.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of (3,4-dichloro-phenyl)-acetic acid methyl ester (44.7 mmol) and hydrazine (447 mmol) in ethanol (100 mL) was stirred at 80° C. for 18 h. After it was cooled to room temperature and concentrated in vacuo, the crude product was purified by crystallization in ethanol to give (3,4-dichloro-phenyl)-acetic acid hydrazide (43 mmol).

Workup

  1. concentrationconcentrated in vacuo
  2. customthe crude product was purified by crystallization in ethanol

Sources & evidence

ORD record
ord-d2aa0b7757e14880b1276b66a56a6599
Source dataset
uspto-grants-2009_11
Patent number
US07615569B2

Reaction notes

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