4-Aminophenyl trifluoromethyl sulphone → 6-(3-chloropyridin-2-yl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-1,2-benzisothiazol-3-amine 1,1-dioxide

Participants

Reaction Steps

The title compound was prepared by reacting the product of Example 1B (0.1521 g, 0.52 mmol) with 4-aminophenyl trifluoromethyl sulphone (0.1417 g, 0.63 mmol) using the procedure as described in Example 1C. MS (ESI+) m/z 454 (M-47)+; (ESI−) m/z 500 (M−H)−; 1H NMR (300 MHz, DMSO-d6) δ 7.58 (dd, J=8.3, 4.6 Hz, 1H), 8.18 (m, 1H), 8.28 (m, 3H), 8.39 (m, 3H), 8.65 (d, J=8.1 Hz, 1H), 8.72 (dd, J=4.6, 1.5 Hz, 1H), 11.42 (s, 1H).

Provenance & Evidence