2-(4-Tert-butylphenyl)ethan-1-amine → HCID 178440868, compound

HRID 1434718Notes

Reaction equation

HRID 1434718 reaction equation
[Cl:1][C:2]1[C:3]([C:8]2[CH:19]=[CH:18][C:11]3[C:12](O)=[N:13][S:14](=[O:16])(=[O:15])[C:10]=3[CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[C:20]([C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][NH2:32])=[CH:26][CH:25]=1)([CH3:23])([CH3:22])[CH3:21]>>[C:20]([C:24]1[CH:25]=[CH:26][C:27]([CH2:30][CH2:31][NH:32][C:12]2[C:11]3[CH:18]=[CH:19][C:8]([C:3]4[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][N:4]=4)=[CH:9][C:10]=3[S:14](=[O:16])(=[O:15])[N:13]=2)=[CH:28][CH:29]=1)([CH3:23])([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 27356892-(4-Tert-butylphenyl)ethan-1-amineHCID 178527199HCID 178527199, compound

Product 1

HCID 178440868HCID 178440868, compound

Procedure

The title compound was prepared by reacting the product of Example 1B (0.1523 g, 0.52 mmol) and 2-(4-tert-butylphenyl)ethylamine (0.1210 g, 0.68 mmol) using the procedure as described in Example 1C. MS (ESI+) m/z 454 (M+H)+; (ESI−) m/z 452 (M−H)−; 1H NMR (300 MHz, CDCl3) δ 1.33 (s, 9H), 3.04 (t, J=7.0 Hz, 2H), 3.92 (q, J=6.6 Hz, 2H), 6.15 (s, 1H), 7.19 (m, 2H), 7.33 (dd,J=8.1, 4.7 Hz, 1H), 7.38 (m, 2H), 7.51 (d, J=7.8 Hz, 1H), 7.86 (dd, J=8.1, 1.0 Hz, 1H), 8.03 (dd, J=8.1, 1.4 Hz, 1H), 8.33 (d, J=1.4 Hz, 1H), 8.62 (dd, J=4.6, 0.8 Hz, 1H).

Sources & evidence

ORD record
ord-ea7e11cfecd24c7ba16cd7045ea6c142
Source dataset
uspto-grants-2009_11
Patent number
US07615570B2

Reaction notes

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