Ethyl 1H-pyrrole-2-carboxylate → HCID 57435146, compound

HRID 1434810Notes

Reaction equation

HRID 1434810 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][CH:8]=[CH:9][CH:10]=1)=[O:5])[CH3:2].[CH:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][C:12]=1[CH2:21][C:22](Cl)=[O:23]>>[CH2:1]([O:3][C:4]([C:6]1[NH:7][CH:8]=[C:9]([C:22](=[O:23])[CH2:21][C:12]2[CH:13]=[CH:14][C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:11]=2)[CH:10]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 255670Ethyl 1H-pyrrole-2-carboxylateHCID 5881152-(2-Naphthyl)acetyl chloride

Product 1

HCID 57435146HCID 57435146, compound

Procedure

4-(2-Naphthalen-2-yl-acetyl)-1H-pyrrole-2-carboxylic acid ethyl ester (141) was synthesized from 1H-pyrrole-2-carboxylic acid ethyl ester and naphthalen-2-yl-acetyl chloride following the procedure described in Example 32. Reaction Conditions: 1,2-dichloromethane/−40° C.→RT. Purification: no purification. LC/MS: 78%.

Workup

  1. customReaction Conditions
  2. customPurification
  3. customno purification

Sources & evidence

ORD record
ord-a14fe991922043e19537358d613b4177
Source dataset
uspto-grants-2009_11
Patent number
US07615572B2

Reaction notes

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