tert-butyl N-(2-hydroxyethyl)carbamate → Methyl 2-(2-tert-butoxycarbonylaminoethoxy)-4-(methyl-thio)benzoate

HRID 1434831Notes

Reaction equation

HRID 1434831 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([S:12][CH3:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][O:1][C:2]1[CH:11]=[C:10]([S:12][CH3:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5])=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 13450750Methyl 2-hydroxy-4-(methylthio)benzoate

Product 1

HCID 57936614Methyl 2-(2-tert-butoxycarbonylaminoethoxy)-4-(methyl-thio)benzoate

Procedure

Methyl 2-(2-tert-butoxycarbonylaminoethoxy)-4-(methyl-thio)benzoate was prepared (12.6 g, 76%) as described in Example 1-D from methyl 2-hyroxy-4-(methylthio)benzoate and 2-tert-butoxycarbonylaminoethanol.

Sources & evidence

ORD record
ord-d5b9c652f75141bea1dc4fbe774919eb
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

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