tert-butyl N-(3-hydroxypropyl)carbamate → Methyl 2-(3-tert-butoxycarbonylaminopropoxy)-4-(methylthio)benzoate

HRID 1434835Notes

Reaction equation

HRID 1434835 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([S:12][CH3:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][CH2:24]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][CH2:24][O:1][C:2]1[CH:11]=[C:10]([S:12][CH3:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5])=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 3838134tert-butyl N-(3-hydroxypropyl)carbamateHCID 13450750Methyl 2-hydroxy-4-(methylthio)benzoate

Product 1

HCID 57936548Methyl 2-(3-tert-butoxycarbonylaminopropoxy)-4-(methylthio)benzoate

Procedure

Methyl 2-(3-tert-butoxycarbonylaminopropoxy)-4-(methylthio)benzoate was prepared (7.0 g, 82%) as described in Example 1-D from methyl 2-hydroxy-4-(methylthio)benzoate and 3-tert-butoxycarbonylaminopropanol.

Sources & evidence

ORD record
ord-10e12019b1c5497498de31ae23dde468
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

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