3-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide → HCID 178425946, compound

HRID 1434840Notes

Reaction equation

HRID 1434840 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:17]=2[C:18](O)=[S:19])[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:26][C:27]1[C:28]([C:33]([NH:35][C:36]2[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][N:37]=2)=[O:34])=[N:29][CH:30]=[CH:31][CH:32]=1>>[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:10][CH2:11][C@H:12]([O:15][C:16]2[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:17]=2[C:18]([NH:26][C:27]2[C:28]([C:33]([NH:35][C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][N:37]=3)=[O:34])=[N:29][CH:30]=[CH:31][CH:32]=2)=[S:19])[CH2:13][CH2:14]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 115578513-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamideHCID 178425921HCID 178425921, compound

Product 1

HCID 178425946HCID 178425946, compoundYield 85%

Procedure

Using a procedure analogous to Example 1-G, 2-(cis-4-t-butoxycarbonylaminocyclohexyloxy)-4-methylthiobenzoic acid and 3-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide gave the title compound as a white solid (2.68 g, 85%).

Sources & evidence

ORD record
ord-403d7c15ef454a098d48d6da6a4b907e
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

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