3-Amino-N-(5-chloropyridin-2-yl)-6-methylpyridine-2-carboxamide → HCID 86620000, compound

HRID 1434843Notes

Reaction equation

HRID 1434843 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:16]=2[C:17](O)=[S:18])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:25][C:26]1[C:27]([C:33]([NH:35][C:36]2[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][N:37]=2)=[O:34])=[N:28][C:29]([CH3:32])=[CH:30][CH:31]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:16]=2[C:17]([NH:25][C:26]2[C:27]([C:33]([NH:35][C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][N:37]=3)=[O:34])=[N:28][C:29]([CH3:32])=[CH:30][CH:31]=2)=[S:18])[CH2:12][CH2:13]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 234387333-Amino-N-(5-chloropyridin-2-yl)-6-methylpyridine-2-carboxamideHCID 178425919HCID 178425919, compound

Product 1

HCID 86620000HCID 86620000, compoundYield 93%

Procedure

Using a procedure analogous to Example 1-G, 2-(1-t-butoxycarbonylpiperidin-4-yloxy)-4-methylthiobenzoic acid and 3-amino-6-methyl-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide gave the title compound as a white solid (7.4 g, 93%).

Sources & evidence

ORD record
ord-e3668d39f73645cda84c7fda04dd4743
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

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