HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate → 3-[2-(1-t-Butoxycarbonylpyrrolidin-3-ylmethoxy)-4-methylthiobenzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 5237175 | — |
| Reactant | N-(5-chloropyridin-2-yl)-3-[2-hydroxy-4-methylthiobenzoylamino]pyridine-2-carboxamide | HCID 136348818 | — |
| Product | 3-[2-(1-t-Butoxycarbonylpyrrolidin-3-ylmethoxy)-4-methylthiobenzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide | HCID 86620007 | — |
Reaction Steps
Using a procedure analogous to Example 38-D, 1-t-butoxycarbonylpyrrolidine-3-methanol (Isomer I) and N-(5-chloropyridin-2-yl)-3-[2-hydroxy-4-methylthiobenzoyl-amino]pyridine-2-carboxamide gave the title compound as a solid (1.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615568B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-b3c4c2e3b5ec4db4aa5f06e51f43b5b2 |
| Source note | uspto-grants-2009_11 |