HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate → 3-[2-(1-t-Butoxycarbonylpyrrolidin-3-ylmethoxy)-4-methylthiobenzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 5237175 | — |
| Reactant | N-(5-chloropyridin-2-yl)-3-[2-hydroxy-4-methylthiobenzoylamino]pyridine-2-carboxamide | HCID 136348818 | — |
| Product | 3-[2-(1-t-Butoxycarbonylpyrrolidin-3-ylmethoxy)-4-methylthiobenzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide | HCID 86620007 | — |
Reaction Steps
Using a procedure analogous to Example 38-D, 1-t-butoxycarbonylpyrrolidin-3-ylmethanol (Isomer II), from the prior example, and N-(5-chloropyridin-2-yl)-3-[2-hydroxy-4-methylthiobenzoylamino]pyridine-2-carboxamide gave the title compound as a white solid (1.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615568B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-6df0445ef8964dd38a3a3fc88063e9d4 |
| Source note | uspto-grants-2009_11 |