Morpholine → 3-Morpholino-1-propanol

Participants

Reaction Conditions

Reaction Steps

To a mixture of morpholine (33 mL, 371 mmol) and CH2Cl2 (650 mL) was added 3-bromopropanol (25.8 g, 186 mmol), and the mixture was heated at 50° C. for 18 h. The reaction was cooled, diluted with CH2Cl2, and filtered. The filtrate was chromatographed (150 g SiO2, CH2Cl2 to 5% 2 M NH3/MeOH in CH2Cl2) to give the title compound as a liquid (27.0 g, 50%).

Provenance & Evidence