3-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide → HCID 68984291, compound

HRID 1434856Notes

Reaction equation

HRID 1434856 reaction equation
[CH:1]([S:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[C:7]([O:14][CH:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]2)[CH:6]=1)([CH3:3])[CH3:2].[NH2:28][C:29]1[C:30]([C:35]([NH:37][C:38]2[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][N:39]=2)=[O:36])=[N:31][CH:32]=[CH:33][CH:34]=1>>[CH:1]([S:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH:28][C:29]2[C:30]([C:35]([NH:37][C:38]3[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][N:39]=3)=[O:36])=[N:31][CH:32]=[CH:33][CH:34]=2)=[O:10])=[C:7]([O:14][CH:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:25])[CH3:26])=[O:22])[CH2:17][CH2:16]2)[CH:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 115578513-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamideHCID 68982624HCID 68982624, compound

Product 1

HCID 68984291HCID 68984291, compoundYield 28%

Procedure

Using a procedure analogous to Example 1-G, 4-iso-propylthio-2-(1-t-butoxycarbonylpiperidin-4-yloxy)benzoic acid and 3-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide gave the title compound as a glass (350 mg, 28%).

Sources & evidence

ORD record
ord-3971a953ce82493fb6d4b971517d2b91
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

Loading…