反应详情

To a 0° C. mixture of (2S)-3-(t-butoxycarbonylamino)-2-(3,4-dimethoxybenzyloxy)propyl triisopropylsilyl ether (1 g, 2.01 mmol) and THF (5 mL) was added 1 M TBAF/THF (2.11 mL, 2.11 mmol). The reaction was stirred for 1 h and satd citric acid (5 mL) and CH2Cl2 were added. The organic layer was partitioned, concentrated, and chromatographed (CH2Cl2 to 50% EtOAc/CH2Cl2) to give the title compound (545 mg, 80%).

1. customThe organic layer was partitioned
2. concentrationconcentrated
3. customchromatographed (CH2Cl2 to 50% EtOAc/CH2Cl2)