HCID 57936499, compound → HCID 68983125, compound

HRID 1434860Notes

Reaction equation

HRID 1434860 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C@H:10]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=1)[CH2:11][OH:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:25][S:26][C:27]1[CH:51]=[CH:50][C:30]([C:31]([NH:33][C:34]2[C:35]([C:40]([NH:42][C:43]3[CH:48]=[CH:47][C:46]([Cl:49])=[CH:45][N:44]=3)=[O:41])=[N:36][CH:37]=[CH:38][CH:39]=2)=[O:32])=[C:29](O)[CH:28]=1>>[Cl:49][C:46]1[CH:47]=[CH:48][C:43]([NH:42][C:40]([C:35]2[C:34]([NH:33][C:31](=[O:32])[C:30]3[CH:29]=[CH:28][C:27]([S:26][CH3:25])=[CH:51][C:50]=3[O:12][CH2:11][C@@H:10]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[CH:39][CH:38]=[CH:37][N:36]=2)=[O:41])=[N:44][CH:45]=1

Participants

3

Reactant 2

HCID 57936499HCID 57936499, compoundHCID 57936562HCID 57936562, compound

Product 1

HCID 68983125HCID 68983125, compoundYield 71%

Procedure

Using a procedure analogous to Example 38-D, (2S)-3-(t-butoxycarbonylamino)-2-(3,4-dimethoxybenzyloxy)propanol and 3-[4-methylthio-2-(hydroxy)benzoylamino]-N-(5-chloro-pyridin-2-yl)pyridine-2-carboxamide gave the title compound as a solid (800 mg, 71%).

Sources & evidence

ORD record
ord-2844c57a670048189989f0810327af3b
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

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