HRID1434860

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(CO[C@H](CO)CNC(=O)OC(C)(C)C)cc1OC

HCID57936499

未命名化合物

结构：CSc1ccc(C(=O)Nc2cccnc2C(=O)Nc2ccc(Cl)cn2)c(O)c1

HCID57936562

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CO[C@@H](CNC(=O)OC(C)(C)C)COc2cc(SC)ccc2C(=O)Nc2cccnc2C(=O)Nc2ccc(Cl)cn2)cc1OC

HCID68983125

未命名化合物

收率 71%

PROCEDURE

实验过程

Using a procedure analogous to Example 38-D, (2S)-3-(t-butoxycarbonylamino)-2-(3,4-dimethoxybenzyloxy)propanol and 3-[4-methylthio-2-(hydroxy)benzoylamino]-N-(5-chloro-pyridin-2-yl)pyridine-2-carboxamide gave the title compound as a solid (800 mg, 71%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2844c57a670048189989f0810327af3b
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07615568B2
来源说明: uspto-grants-2009_11

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH2:9][C@H:10]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=1)[CH2:11][OH:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:25][S:26][C:27]1[CH:51]=[CH:50][C:30]([C:31]([NH:33][C:34]2[C:35]([C:40]([NH:42][C:43]3[CH:48]=[CH:47][C:46]([Cl:49])=[CH:45][N:44]=3)=[O:41])=[N:36][CH:37]=[CH:38][CH:39]=2)=[O:32])=[C:29](O)[CH:28]=1>>[Cl:49][C:46]1[CH:47]=[CH:48][C:43]([NH:42][C:40]([C:35]2[C:34]([NH:33][C:31](=[O:32])[C:30]3[CH:29]=[CH:28][C:27]([S:26][CH3:25])=[CH:51][C:50]=3[O:12][CH2:11][C@@H:10]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[CH:39][CH:38]=[CH:37][N:36]=2)=[O:41])=[N:44][CH:45]=1