Methyl iodide → HCID 57936579, compound

HRID 1434863Notes

Reaction equation

[CH:1]([Si:4]([O:11][CH2:12][C@@H:13]([OH:23])[CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([CH:8]([CH3:10])[CH3:9])[CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].[CH3:24]I>>[CH:8]([Si:4]([O:11][CH2:12][C@@H:13]([O:23][CH3:24])[CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([CH:5]([CH3:7])[CH3:6])[CH:1]([CH3:3])[CH3:2])([CH3:9])[CH3:10]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 57936617HCID 57936617, compound

Product 1

HCID 57936579HCID 57936579, compoundYield 81%

Procedure

Using a procedure analogous to Example 57-B, (2S)-3-(t-butoxycarbonylamino)-2-hydroxypropyl triisopropylsilyl ether and methyl iodide gave the title compound (4.2 g, 81%).

Sources & evidence

ORD record: ord-808ff5526483404d81acf1114d325008
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615568B2

Reaction notes

Loading…