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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434865Generated: October 30, 2026

Dimethyl Sulfide → tert-Butyl 3-(hydroxymethyl)azetidine-1-carboxylate

https://huagongshe.com/reaction/1434865

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl SulfideHCID 1068—
Reactant1-Boc-Azetidine-3-carboxylic acidHCID 2755981—
Producttert-Butyl 3-(hydroxymethyl)azetidine-1-carboxylateHCID 10583745—

Reaction Steps

Using a procedure analogous to Example 40-B (using Me2S.BH3), 1-t-butoxycarbonylazetidine-3-carboxylic acid gave the title compound (3.0 g, quantitative).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07615568B2
Source datasetuspto-grants-2009_11
ORD IDord-92a2b9c190684355b64238e4614ffc59
Source noteuspto-grants-2009_11