HRID1434866

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10583745

tert-Butyl 3-(hydroxymethyl)azetidine-1-carboxylate

C9H17NO3

结构：CSc1ccc(C(=O)Nc2cccnc2C(=O)Nc2ccc(Cl)cn2)c(O)c1

HCID57936562

未命名化合物

PRODUCTS

生成物

结构：CSc1ccc(C(=O)Nc2cccnc2C(=O)Nc2ccc(Cl)cn2)c(OCC2CN(C(=O)OC(C)(C)C)C2)c1

HCID68981457

未命名化合物

收率 78%

PROCEDURE

实验过程

Using a procedure analogous to Example 38-D, 1-t-butoxycarbonyl-3-hydroxymethylazetidine and N-(5-chloro-pyridin-2-yl)-3-[2-hydroxy-4-(methylthio)benzoylamino]-pyridine-2-carboxamide gave the title compound as a white solid (1.1 g, 78%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bca0435af8ab4be29f003c0fdb004244
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07615568B2
来源说明: uspto-grants-2009_11

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:11][CH:10]([CH2:12][OH:13])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([NH:21][C:22]([C:24]2[C:29]([NH:30][C:31](=[O:41])[C:32]3[CH:37]=[CH:36][C:35]([S:38][CH3:39])=[CH:34][C:33]=3O)=[CH:28][CH:27]=[CH:26][N:25]=2)=[O:23])=[N:19][CH:20]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([NH:21][C:22]([C:24]2[C:29]([NH:30][C:31](=[O:41])[C:32]3[CH:33]=[CH:34][C:35]([S:38][CH3:39])=[CH:36][C:37]=3[O:13][CH2:12][CH:10]3[CH2:11][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9]3)=[CH:28][CH:27]=[CH:26][N:25]=2)=[O:23])=[N:19][CH:20]=1