Tert-butyl 4-hydroxypiperidine-1-carboxylate → HCID 57936642, compound

HRID 1434871Notes

Reaction equation

HRID 1434871 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([S:12][CH2:13][CH3:14])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:15]([N:22]1[CH2:27][CH2:26][CH:25](O)[CH2:24][CH2:23]1)([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]>>[C:18]([O:17][C:15]([N:22]1[CH2:27][CH2:26][CH:25]([O:1][C:2]2[CH:11]=[C:10]([S:12][CH2:13][CH3:14])[CH:9]=[CH:8][C:3]=2[C:4]([O:6][CH3:7])=[O:5])[CH2:24][CH2:23]1)=[O:16])([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 57936526HCID 57936526, compound

Product 1

HCID 57936642HCID 57936642, compoundYield 46%

Procedure

Using a method similar to Example 1-D, methyl 2-hydroxy-4-(ethylthio)benzoate and 1-Boc-4-hydroxy-piperidine gave the title compound (5.0 g, 12.64 mmol 46%).

Sources & evidence

ORD record
ord-310111211f9c4b4ab10bcc408a355156
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

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