Dichloromethane → HCID 57936580, compound

Participants

Reaction Steps

To a mixture of 2-hydroxy-4-(methylthiomethyl)benzoic acid (3.96 g, 20 mmol), CH2Cl2 (75 mL), and MeOH (15 mL) was added a solution of 2 M trimethylsilyldiazomethane (TMSCHN2) in hexane (10.5 mL, 21 mmol) over 30 min. After stirring for 10 min, the reaction was concentrated and vacuum dried. The residue was chromatographed (250 g SiO2, hexanes to 5% EtOAc/hexanes) to give the title compound as a colorless oil (3.96 g, 93%).

Provenance & Evidence