3-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide → HCID 57936494, compound

HRID 1434878Notes

Reaction equation

HRID 1434878 reaction equation
[CH3:1][S:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=O)=[C:6]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]2)[CH:5]=1.[NH2:27][C:28]1[C:29]([C:34]([NH:36][C:37]2[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][N:38]=2)=[O:35])=[N:30][CH:31]=[CH:32][CH:33]=1>>[CH3:1][S:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH:27][C:28]2[C:29]([C:34]([NH:36][C:37]3[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][N:38]=3)=[O:35])=[N:30][CH:31]=[CH:32][CH:33]=2)=[O:10])=[C:6]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:25])([CH3:26])[CH3:24])=[O:21])[CH2:16][CH2:15]2)[CH:5]=1

Participants

3

Reactant 2

HCID 115578513-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamideHCID 59721164HCID 59721164, compound

Product 1

HCID 57936494HCID 57936494, compoundYield 43%

Procedure

Using a procedure analogous to Example 1-G, 3-[4-(methylthiomethyl)-2-(1-t-butoxycarbonylpiperidin-4-yloxy)-benzoic acid and 3-amino-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide gave the title compound as a white solid (751 mg, 43%).

Sources & evidence

ORD record
ord-116051a75ec344899e1d8aa897ca8d9e
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

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