Sodium Azide → HCID 91005463, compound

Participants

Reaction Steps

A dimethylformamide (3.0 ml) solution of Compound 3 (27 mg, 0.078 mmol) and sodium azide was stirred for 1.5 hours at room temperature and for 2 hours at 100° C. in a stream of nitrogen. The solvent was distilled off under reduced pressure, and then a small amount of water was added to the residue, followed by extracting the mixture with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate. Then, the solvent was distilled off under reduced pressure to obtain Compound 4 (28 mg, quant. in 2 steps) as a yellow oily substance.

Provenance & Evidence