Ammonia → HCID 67326951, compound

Participants

Reaction Steps

In a nitrogen stream, triphenylphosphine (49 mg, 0.19 mmol) was added to a pyridine solution (3.0 ml) of Compound 4 (28 mg, 0.095 mmol), and the mixture was stirred for 3 hours at room temperature. A 28% aqueous solution of ammonia (5.0 ml) was added, and the mixture was stirred further for 14 hours. Then, the solvent was distilled off under reduced pressure to obtain 5′-amino-5′-deoxy-5-methyl-2′-O,4′-C-methyleneuridine (Compound 5) as a crude product.

Provenance & Evidence