Hydrochloric Acid → HCID 178420844, compound

HRID 1434886Notes

Reaction equation

HRID 1434886 reaction equation
Cl.[NH2:2][C:3]1[C:8]([NH2:9])=[C:7]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH:6]=[CH:5][N:4]=1.[CH2:15](OC(O)O)C>>[S:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:7]1[CH:6]=[CH:5][N:4]=[C:3]2[NH:2][CH:15]=[N:9][C:8]=12

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 5231668OrthoameisensaureathylesterHCID 579367942,3-Diamino-4-(2-thienyl)pyridine

Product 1

HCID 178420844HCID 178420844, compoundYield 96%

Procedure

Hydrochloric acid (35 wt %, 1.47 ml) was added to 2,3-diamino-4-(2-thienyl)pyridine (1.46 g, 7.61 mmol) and orthoformic acid ethyl ester (40.5 ml). This solution was stirred at room temperature for 3 days and then filtered. The residue was washed with ether to give 7-(2-thienyl)-3H-imidazo[4,5-b]pyridine (1.74 g, 96%).

Workup

  1. filtrationfiltered
  2. washThe residue was washed with ether

Sources & evidence

ORD record
ord-9818a8c312044bb88402cdd5a41a6e80
Source dataset
uspto-grants-2009_11
Patent number
US07615628B2

Reaction notes

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