反应详情

To a solution of 7-(2-thienyl)-5-ethoxycarbonylamino-3H-imidazo[4,5-b]pyridine (1.21 g, 3.72 mmol) in ethanol (130 ml), potassium hydroxide (7.29 g) was added and heated under reflux for 4 hours. To this solution, an aqueous ammonium chloride solution (7.65 g/26 ml) was added, followed by evaporation under reduced pressure to remove the solvent. The product was isolated by silica gel column chromatography (methylene chloride:ethanol=9:1 to 7:3) to give 5-amino-7-(2-thienyl)-3H-imidazo[4,5-b]pyridine (870 mg).

1. temperatureheated
2. temperatureunder reflux for 4 hours
3. customfollowed by evaporation under reduced pressure
4. customto remove the solvent
5. customThe product was isolated by silica gel column chromatography (methylene chloride:ethanol=9:1 to 7:3)