反应详情

4-Iodo-2-methylsulfanyl-pyrimidine (2.5 g, 10 mmol), (5-Bromo-thiophen-2-yl)-tributyl-stannane (4.9 g, 11 mmol) and PdCl2 (702 mg, 1 mmol) were heated to 105° C. in toluene (30 ml) for 2 hours. The reaction mixture was poured on water and extracted three times with EtOAc. The combined organic phases were dried over sodium sulfate, filtered, evaporated to dryness and purified via chromatography on silicagel (acetone/hexanes:0/100 to 3/97) to give the title compound as colourless foam. Yield: 1.6 g (55%).

1. additionThe reaction mixture was poured on water
2. extractionextracted three times with EtOAc
3. dry with materialThe combined organic phases were dried over sodium sulfate
4. filtrationfiltered
5. customevaporated to dryness
6. custompurified via chromatography on silicagel (acetone/hexanes:0/100 to 3/97)