Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1434922Generated: November 1, 2026

2-(Methylthio)-4-(tributylstannyl)pyrimidine → (E)-3-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-acrylic acid methyl ester

https://huagongshe.com/reaction/1434922

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Methylthio)-4-(tributylstannyl)pyrimidineHCID 2763261—
Reactant(E)-methyl 3-(5-bromothiophen-2-yl)acrylateHCID 25417100—
Product(E)-3-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-acrylic acid methyl esterHCID 5793632845%

Reaction Steps

(E)-3-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-acrylic acid methyl ester was prepared analogous to Step A of Method D, using (E)-3-(5-bromo-thiophen-2-yl)-acrylic acid methyl ester and 2-methylsulfanyl-4-tributylstannanyl-pyrimidine. Yield: 45%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07615562B2
Source datasetuspto-grants-2009_11
ORD IDord-086545ff375a4d74988dc106629f886e
Source noteuspto-grants-2009_11