Nitromethane → 3-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-4-nitro-butyric acid methyl ester

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Reaction Steps

A solution of (E)-3-[5-(2-methylsulfanyl-pyrimidin-4-yl)-thiophen-2-yl]-acrylic acid methyl ester (200 mg, 0.684 mmol), nitromethane (3 ml) and Triton B (0.3 ml) was heated to 80° C. for 4 hours. After cooling, the mixture was diluted with EtOAc and washed with saturated ammonium chloride solution, water and brine. Drying over sodium sulfate and evaporation gave a red-brown oil. Yield: 100 mg (41%)

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