HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrimidine, 2,4-dichloro-5-methyl- → 4-[5-(2-Chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrimidine, 2,4-dichloro-5-methyl- | HCID 74508 | — |
| Reactant | 4-(2-Thienyl)butanoic acid methyl ester | HCID 140766 | — |
| Product | 4-[5-(2-Chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester | HCID 57936306 | 12% |
Reaction Steps
4-[5-(2-Chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester was prepared analogous to Step B of Method A, starting from 4-thiophen-2-yl-butyric acid methyl ester and 2,4-dichloro-5-methyl-pyrimidine. Yield: 12%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615562B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-c5a93e50418242fd91a2579668c4ca5f |
| Source note | uspto-grants-2009_11 |