HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-2,2,6,6-tetramethylpiperidine → 4-{5-[5-Methyl-2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-2,2,6,6-tetramethylpiperidine | HCID 37524 | — |
| Reactant | 4-[5-(2-Chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester | HCID 57936306 | — |
| Product | 4-{5-[5-Methyl-2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butyric acid methyl ester | HCID 57936148 | 60% |
Reaction Steps
4-{5-[5-Methyl-2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butyric acid methyl ester was prepared analogous to Step C of Method A, starting from 4-[5-(2-chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester and added 2,2,6,6-tetramethyl-piperidin-4-ylamine. Yield: 60%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615562B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-1119ce3a0c7a4af68964bf3c1dc56e71 |
| Source note | uspto-grants-2009_11 |