Sodium hydride → HCID 57936191, compound

Participants

Reaction Conditions

Reaction Steps

2-Methylsulfanyl-4-(1H-pyrrol-3-yl)-pyrimidine (260 mg, 1.36 mmol) was added to a suspension of fat free sodium hydride (39 mg, 1.63 mmol) in 5 ml of THF. The mixture was heated to 50° C. for 20 minutes. Then, 3-bromo-propionic acid methyl ester (0.156 ml, 1.36 mmol) was added and the temperature was increased to 80° C. After 14 hours, the mixture was cooled, quenched with water and extracted with ether. The combined organic layers were washed with brine, dried over sodium sulfate and evaporated. The crude product was used without further purification. Yield: 302 mg (80%).

Provenance & Evidence