(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine → HCID 11304494, compound

HRID 1434937Notes

Reaction equation

HRID 1434937 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:3]=1.[S:19]1[CH:23]=[CH:22][CH:21]=[C:20]1[CH:24]1[CH2:26][CH:25]1[C:27]1([OH:30])[CH2:29][CH2:28]1>>[CH3:15][C:13]1([CH3:16])[CH2:14][CH:9]([NH:8][C:4]2[N:3]=[C:2]([C:23]3[S:19][C:20]([CH:24]4[CH2:26][CH:25]4[C:27]4([OH:30])[CH2:29][CH2:28]4)=[CH:21][CH:22]=3)[CH:7]=[CH:6][N:5]=2)[CH2:10][C:11]([CH3:18])([CH3:17])[NH:12]1

Participants

3

Reactant 2

HCID 57936167(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amineHCID 69063491HCID 69063491, compound

Product 1

HCID 11304494HCID 11304494, compound

Procedure

The title compound was prepared analogous to Method C, starting from (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and 2′-thiophen-2-yl-bicyclopropyl-1-ol (prepared by cyclopropanation of 2-thiophen-2-yl-cyclopropanecarboxylic acid methyl ester, J. Org. Chem. 1993, 502).

Sources & evidence

ORD record
ord-9f7e876e35ee441b8adb8ab010baddd8
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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