(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine → 2,3,3-Trimethyl-4-{5-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butan-2-ol
Reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:3]=1.[CH3:19][C:20]([OH:31])([C:22]([CH3:30])([CH3:29])[CH2:23][C:24]1[S:25][CH:26]=[CH:27][CH:28]=1)[CH3:21]>>[CH3:21][C:20]([OH:31])([C:22]([CH3:30])([CH3:29])[CH2:23][C:24]1[S:25][C:26]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]3[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]3)[N:3]=2)=[CH:27][CH:28]=1)[CH3:19]Participants
3
Procedure
The title compound was prepared analogous to Method C, starting from (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and 2,3,3-trimethyl-4-thiophen-2-yl-butan-2-ol (prepared from 2,2-dimethyl-3-thiophen-2-yl-propionic acid by esterification with diazomethane and treatment with MeMgBr (Step A of Method A)).
Sources & evidence
- ORD record
- ord-94781fa65daf4805a812c0dd026a9e26
- Source dataset
- uspto-grants-2009_11
- Patent number
- US07615562B2
Reaction notes
Loading…