Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | HCID 72822011 | HCID 72822011 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 11259118 | HCID 11259118 | — |
Reaction Steps
Compound of Example 51 (366 mg, 0.79 mmol) was dissolved in 20 ml THF and 0.35 ml of LAH (˜2.3 M suspension in THF) added dropwise at room temperature. Afterwards this mixture was stirred for 2 hours at 60° C. After cooling to room temperature 40 ml of saturated sodium sulfate solution was added and stirred for 15 minutes. The title compound was isolated by extraction with EtOAc and purified by chromatography on silicagel (DCM/MeOH/ammonia:95/5/0.5). Yield: 160 mg (47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07615562B2 |
|---|
| Source dataset | uspto-grants-2009_11 |
|---|
| ORD ID | ord-de3c6c9c16d24722983d789c0455a094 |
|---|
| Source note | uspto-grants-2009_11 |
|---|
