HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1-Benzothiophen-2-yl)-2-chloropyrimidine → (2R,4R)-4-(4-Benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)-piperidine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1-Benzothiophen-2-yl)-2-chloropyrimidine | HCID 14745025 | — |
| Reactant | (2R,4R)-1-tert-butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate | HCID 54209755 | — |
| Product | (2R,4R)-4-(4-Benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)-piperidine-2-carboxylic acid methyl ester | HCID 57936323 | — |
Reaction Steps
The title compound was prepared from 4-benzo[b]thiophen-2-yl-2-chloro-pyrimidine and (2R,4R)-4-amino-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester according to Step C of Method A. Yield 45 mg (45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615562B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-49ba57c6d7704b459bcd3a2ac456c073 |
| Source note | uspto-grants-2009_11 |