2-(Tributylstannyl)pyridine → [4-(4-Pyridin-2-yl-phenyl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

HRID 1434988Notes

Reaction equation

HRID 1434988 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:20][C:19]([CH3:22])([CH3:21])[NH:18][C:17]([CH3:24])([CH3:23])[CH2:16]3)[N:9]=2)=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=1)CCC>>[N:31]1[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=1[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:16][C:17]([CH3:24])([CH3:23])[NH:18][C:19]([CH3:22])([CH3:21])[CH2:20]3)[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6077842-(Tributylstannyl)pyridineHCID 57936126[4-(4-Bromophenyl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Product 1

HCID 57936217[4-(4-Pyridin-2-yl-phenyl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Procedure

The title compound was prepared analogous to Step D of Example 172, starting from [4-(4-bromophenyl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and 2-tributylstannanyl-pyridine. Yield: 85 mg (44%).

Sources & evidence

ORD record
ord-7bca544d976847e4886d59bc3cf9e9ca
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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